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In particular, the PI3K/AKT axis converts phosphatidylinositol-4,5-bisphosphate (PIP 2 ) to phosphatidylinositol 3,4,5-trisphosphate (PIP 3 )

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They then added a synbiotic capsule (plus fluoxetine) or placebo (plus fluoxetine) to the treatment for 6 weeks